Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation
Identifieur interne : 000270 ( Main/Exploration ); précédent : 000269; suivant : 000271Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation
Auteurs : Sara Breid [Allemagne] ; Maria E. Bernis [Allemagne] ; Julius T. Babila [Allemagne] ; Maria C. Garza [Canada] ; Holger Wille [Canada] ; Gültekin Tamgüney [Allemagne]Source :
- Journal of Virology [ 0022-538X ] ; 2016.
Abstract
α-Synuclein is a soluble, cellular protein that in a number of neurodegenerative diseases, including Parkinson's disease and multiple system atrophy, forms pathological deposits of protein aggregates. Because misfolded α-synuclein has some characteristics that resemble those of prions, we investigated its potential to induce disease after intraperitoneal or intraglossal challenge injection into bigenic Tg(M83+/−:
Url:
DOI: 10.1128/JVI.01399-16
PubMed: 27489279
PubMed Central: 5044858
Affiliations:
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<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>α-Synuclein is a soluble, cellular protein that in a number of neurodegenerative diseases, including Parkinson's disease and multiple system atrophy, forms pathological deposits of protein aggregates. Because misfolded α-synuclein has some characteristics that resemble those of prions, we investigated its potential to induce disease after intraperitoneal or intraglossal challenge injection into bigenic Tg(M83<sup>+/−</sup>
:<italic>Gfap</italic>
-luc<sup>+/−</sup>
) mice, which express the A53T mutant of human α-synuclein and firefly luciferase. After a single intraperitoneal injection with α-synuclein fibrils, four of five mice developed paralysis and α-synuclein pathology in the central nervous system, with a median incubation time of 229 ± 17 days. Diseased mice accumulated aggregates of Sarkosyl-insoluble and phosphorylated α-synuclein in the brain and spinal cord, which colocalized with ubiquitin and p62 and were accompanied by gliosis. In contrast, only one of five mice developed α-synuclein pathology in the central nervous system after intraglossal injection with α-synuclein fibrils, after 285 days. These findings are novel and important because they show that, similar to prions, α-synuclein prionoids can neuroinvade the central nervous system after intraperitoneal or intraglossal injection and can cause neuropathology and disease.
</p>
<p><bold>IMPORTANCE</bold>
Synucleinopathies are neurodegenerative diseases that are characterized by the pathological presence of aggregated α-synuclein in cells of the nervous system. Previous studies have shown that α-synuclein aggregates made of recombinant protein or derived from brains of patients can spread in the central nervous system in a spatiotemporal manner when inoculated into the brains of animals and can induce pathology and neurologic disease, suggesting that misfolded α-synuclein can behave similarly to prions. Here we show that α-synuclein inoculation into the peritoneal cavity or the tongue in mice overexpressing α-synuclein causes neurodegeneration after neuroinvasion from the periphery, which further corroborates the prionoid character of misfolded α-synuclein.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Spillantini, Mg" uniqKey="Spillantini M">MG Spillantini</name>
</author>
<author><name sortKey="Crowther, Ra" uniqKey="Crowther R">RA Crowther</name>
</author>
<author><name sortKey="Jakes, R" uniqKey="Jakes R">R Jakes</name>
</author>
<author><name sortKey="Cairns, Nj" uniqKey="Cairns N">NJ Cairns</name>
</author>
<author><name sortKey="Lantos, Pl" uniqKey="Lantos P">PL Lantos</name>
</author>
<author><name sortKey="Goedert, M" uniqKey="Goedert M">M Goedert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wakabayashi, K" uniqKey="Wakabayashi K">K Wakabayashi</name>
</author>
<author><name sortKey="Yoshimoto, M" uniqKey="Yoshimoto M">M Yoshimoto</name>
</author>
<author><name sortKey="Tsuji, S" uniqKey="Tsuji S">S Tsuji</name>
</author>
<author><name sortKey="Takahashi, H" uniqKey="Takahashi H">H Takahashi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Spillantini, Mg" uniqKey="Spillantini M">MG Spillantini</name>
</author>
<author><name sortKey="Crowther, Ra" uniqKey="Crowther R">RA Crowther</name>
</author>
<author><name sortKey="Jakes, R" uniqKey="Jakes R">R Jakes</name>
</author>
<author><name sortKey="Hasegawa, M" uniqKey="Hasegawa M">M Hasegawa</name>
</author>
<author><name sortKey="Goedert, M" uniqKey="Goedert M">M Goedert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Polymeropoulos, Mh" uniqKey="Polymeropoulos M">MH Polymeropoulos</name>
</author>
<author><name sortKey="Lavedan, C" uniqKey="Lavedan C">C Lavedan</name>
</author>
<author><name sortKey="Leroy, E" uniqKey="Leroy E">E Leroy</name>
</author>
<author><name sortKey="Ide, Se" uniqKey="Ide S">SE Ide</name>
</author>
<author><name sortKey="Dehejia, A" uniqKey="Dehejia A">A Dehejia</name>
</author>
<author><name sortKey="Dutra, A" uniqKey="Dutra A">A Dutra</name>
</author>
<author><name sortKey="Pike, B" uniqKey="Pike B">B Pike</name>
</author>
<author><name sortKey="Root, H" uniqKey="Root H">H Root</name>
</author>
<author><name sortKey="Rubenstein, J" uniqKey="Rubenstein J">J Rubenstein</name>
</author>
<author><name sortKey="Boyer, R" uniqKey="Boyer R">R Boyer</name>
</author>
<author><name sortKey="Stenroos, Es" uniqKey="Stenroos E">ES Stenroos</name>
</author>
<author><name sortKey="Chandrasekharappa, S" uniqKey="Chandrasekharappa S">S Chandrasekharappa</name>
</author>
<author><name sortKey="Athanassiadou, A" uniqKey="Athanassiadou A">A Athanassiadou</name>
</author>
<author><name sortKey="Papapetropoulos, T" uniqKey="Papapetropoulos T">T Papapetropoulos</name>
</author>
<author><name sortKey="Johnson, Wg" uniqKey="Johnson W">WG Johnson</name>
</author>
<author><name sortKey="Lazzarini, Am" uniqKey="Lazzarini A">AM Lazzarini</name>
</author>
<author><name sortKey="Duvoisin, Rc" uniqKey="Duvoisin R">RC Duvoisin</name>
</author>
<author><name sortKey="Di Iorio, G" uniqKey="Di Iorio G">G Di Iorio</name>
</author>
<author><name sortKey="Golbe, Li" uniqKey="Golbe L">LI Golbe</name>
</author>
<author><name sortKey="Nussbaum, Rl" uniqKey="Nussbaum R">RL Nussbaum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Singleton, Ab" uniqKey="Singleton A">AB Singleton</name>
</author>
<author><name sortKey="Farrer, M" uniqKey="Farrer M">M Farrer</name>
</author>
<author><name sortKey="Johnson, J" uniqKey="Johnson J">J Johnson</name>
</author>
<author><name sortKey="Singleton, A" uniqKey="Singleton A">A Singleton</name>
</author>
<author><name sortKey="Hague, S" uniqKey="Hague S">S Hague</name>
</author>
<author><name sortKey="Kachergus, J" uniqKey="Kachergus J">J Kachergus</name>
</author>
<author><name sortKey="Hulihan, M" uniqKey="Hulihan M">M Hulihan</name>
</author>
<author><name sortKey="Peuralinna, T" uniqKey="Peuralinna T">T Peuralinna</name>
</author>
<author><name sortKey="Dutra, A" uniqKey="Dutra A">A Dutra</name>
</author>
<author><name sortKey="Nussbaum, R" uniqKey="Nussbaum R">R Nussbaum</name>
</author>
<author><name sortKey="Lincoln, S" uniqKey="Lincoln S">S Lincoln</name>
</author>
<author><name sortKey="Crawley, A" uniqKey="Crawley A">A Crawley</name>
</author>
<author><name sortKey="Hanson, M" uniqKey="Hanson M">M Hanson</name>
</author>
<author><name sortKey="Maraganore, D" uniqKey="Maraganore D">D Maraganore</name>
</author>
<author><name sortKey="Adler, C" uniqKey="Adler C">C Adler</name>
</author>
<author><name sortKey="Cookson, Mr" uniqKey="Cookson M">MR Cookson</name>
</author>
<author><name sortKey="Muenter, M" uniqKey="Muenter M">M Muenter</name>
</author>
<author><name sortKey="Baptista, M" uniqKey="Baptista M">M Baptista</name>
</author>
<author><name sortKey="Miller, D" uniqKey="Miller D">D Miller</name>
</author>
<author><name sortKey="Blancato, J" uniqKey="Blancato J">J Blancato</name>
</author>
<author><name sortKey="Hardy, J" uniqKey="Hardy J">J Hardy</name>
</author>
<author><name sortKey="Gwinn Hardy, K" uniqKey="Gwinn Hardy K">K Gwinn-Hardy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chartier Harlin, Mc" uniqKey="Chartier Harlin M">MC Chartier-Harlin</name>
</author>
<author><name sortKey="Kachergus, J" uniqKey="Kachergus J">J Kachergus</name>
</author>
<author><name sortKey="Roumier, C" uniqKey="Roumier C">C Roumier</name>
</author>
<author><name sortKey="Mouroux, V" uniqKey="Mouroux V">V Mouroux</name>
</author>
<author><name sortKey="Douay, X" uniqKey="Douay X">X Douay</name>
</author>
<author><name sortKey="Lincoln, S" uniqKey="Lincoln S">S Lincoln</name>
</author>
<author><name sortKey="Levecque, C" uniqKey="Levecque C">C Levecque</name>
</author>
<author><name sortKey="Larvor, L" uniqKey="Larvor L">L Larvor</name>
</author>
<author><name sortKey="Andrieux, J" uniqKey="Andrieux J">J Andrieux</name>
</author>
<author><name sortKey="Hulihan, M" uniqKey="Hulihan M">M Hulihan</name>
</author>
<author><name sortKey="Waucquier, N" uniqKey="Waucquier N">N Waucquier</name>
</author>
<author><name sortKey="Defebvre, L" uniqKey="Defebvre L">L Defebvre</name>
</author>
<author><name sortKey="Amouyel, P" uniqKey="Amouyel P">P Amouyel</name>
</author>
<author><name sortKey="Farrer, M" uniqKey="Farrer M">M Farrer</name>
</author>
<author><name sortKey="Destee, A" uniqKey="Destee A">A Destee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ibanez, P" uniqKey="Ibanez P">P Ibanez</name>
</author>
<author><name sortKey="Bonnet, Am" uniqKey="Bonnet A">AM Bonnet</name>
</author>
<author><name sortKey="Debarges, B" uniqKey="Debarges B">B Debarges</name>
</author>
<author><name sortKey="Lohmann, E" uniqKey="Lohmann E">E Lohmann</name>
</author>
<author><name sortKey="Tison, F" uniqKey="Tison F">F Tison</name>
</author>
<author><name sortKey="Pollak, P" uniqKey="Pollak P">P Pollak</name>
</author>
<author><name sortKey="Agid, Y" uniqKey="Agid Y">Y Agid</name>
</author>
<author><name sortKey="Durr, A" uniqKey="Durr A">A Durr</name>
</author>
<author><name sortKey="Brice, A" uniqKey="Brice A">A Brice</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Braak, H" uniqKey="Braak H">H Braak</name>
</author>
<author><name sortKey="Del Tredici, K" uniqKey="Del Tredici K">K Del Tredici</name>
</author>
<author><name sortKey="Rub, U" uniqKey="Rub U">U Rub</name>
</author>
<author><name sortKey="De Vos, Ra" uniqKey="De Vos R">RA de Vos</name>
</author>
<author><name sortKey="Jansen Steur, En" uniqKey="Jansen Steur E">EN Jansen Steur</name>
</author>
<author><name sortKey="Braak, E" uniqKey="Braak E">E Braak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lue, Lf" uniqKey="Lue L">LF Lue</name>
</author>
<author><name sortKey="Walker, Dg" uniqKey="Walker D">DG Walker</name>
</author>
<author><name sortKey="Adler, Ch" uniqKey="Adler C">CH Adler</name>
</author>
<author><name sortKey="Shill, H" uniqKey="Shill H">H Shill</name>
</author>
<author><name sortKey="Tran, H" uniqKey="Tran H">H Tran</name>
</author>
<author><name sortKey="Akiyama, H" uniqKey="Akiyama H">H Akiyama</name>
</author>
<author><name sortKey="Sue, Li" uniqKey="Sue L">LI Sue</name>
</author>
<author><name sortKey="Caviness, J" uniqKey="Caviness J">J Caviness</name>
</author>
<author><name sortKey="Sabbagh, Mn" uniqKey="Sabbagh M">MN Sabbagh</name>
</author>
<author><name sortKey="Beach, Tg" uniqKey="Beach T">TG Beach</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Jy" uniqKey="Li J">JY Li</name>
</author>
<author><name sortKey="Englund, E" uniqKey="Englund E">E Englund</name>
</author>
<author><name sortKey="Holton, Jl" uniqKey="Holton J">JL Holton</name>
</author>
<author><name sortKey="Soulet, D" uniqKey="Soulet D">D Soulet</name>
</author>
<author><name sortKey="Hagell, P" uniqKey="Hagell P">P Hagell</name>
</author>
<author><name sortKey="Lees, Aj" uniqKey="Lees A">AJ Lees</name>
</author>
<author><name sortKey="Lashley, T" uniqKey="Lashley T">T Lashley</name>
</author>
<author><name sortKey="Quinn, Np" uniqKey="Quinn N">NP Quinn</name>
</author>
<author><name sortKey="Rehncrona, S" uniqKey="Rehncrona S">S Rehncrona</name>
</author>
<author><name sortKey="Bjorklund, A" uniqKey="Bjorklund A">A Bjorklund</name>
</author>
<author><name sortKey="Widner, H" uniqKey="Widner H">H Widner</name>
</author>
<author><name sortKey="Revesz, T" uniqKey="Revesz T">T Revesz</name>
</author>
<author><name sortKey="Lindvall, O" uniqKey="Lindvall O">O Lindvall</name>
</author>
<author><name sortKey="Brundin, P" uniqKey="Brundin P">P Brundin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kordower, Jh" uniqKey="Kordower J">JH Kordower</name>
</author>
<author><name sortKey="Chu, Y" uniqKey="Chu Y">Y Chu</name>
</author>
<author><name sortKey="Hauser, Ra" uniqKey="Hauser R">RA Hauser</name>
</author>
<author><name sortKey="Freeman, Tb" uniqKey="Freeman T">TB Freeman</name>
</author>
<author><name sortKey="Olanow, Cw" uniqKey="Olanow C">CW Olanow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Conway, Ka" uniqKey="Conway K">KA Conway</name>
</author>
<author><name sortKey="Harper, Jd" uniqKey="Harper J">JD Harper</name>
</author>
<author><name sortKey="Lansbury, Pt" uniqKey="Lansbury P">PT Lansbury</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Desplats, P" uniqKey="Desplats P">P Desplats</name>
</author>
<author><name sortKey="Lee, Hj" uniqKey="Lee H">HJ Lee</name>
</author>
<author><name sortKey="Bae, Ej" uniqKey="Bae E">EJ Bae</name>
</author>
<author><name sortKey="Patrick, C" uniqKey="Patrick C">C Patrick</name>
</author>
<author><name sortKey="Rockenstein, E" uniqKey="Rockenstein E">E Rockenstein</name>
</author>
<author><name sortKey="Crews, L" uniqKey="Crews L">L Crews</name>
</author>
<author><name sortKey="Spencer, B" uniqKey="Spencer B">B Spencer</name>
</author>
<author><name sortKey="Masliah, E" uniqKey="Masliah E">E Masliah</name>
</author>
<author><name sortKey="Lee, Sj" uniqKey="Lee S">SJ Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Volpicelli Daley, La" uniqKey="Volpicelli Daley L">LA Volpicelli-Daley</name>
</author>
<author><name sortKey="Luk, Kc" uniqKey="Luk K">KC Luk</name>
</author>
<author><name sortKey="Patel, Tp" uniqKey="Patel T">TP Patel</name>
</author>
<author><name sortKey="Tanik, Sa" uniqKey="Tanik S">SA Tanik</name>
</author>
<author><name sortKey="Riddle, Dm" uniqKey="Riddle D">DM Riddle</name>
</author>
<author><name sortKey="Stieber, A" uniqKey="Stieber A">A Stieber</name>
</author>
<author><name sortKey="Meaney, Df" uniqKey="Meaney D">DF Meaney</name>
</author>
<author><name sortKey="Trojanowski, Jq" uniqKey="Trojanowski J">JQ Trojanowski</name>
</author>
<author><name sortKey="Lee, Vm" uniqKey="Lee V">VM Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luk, Kc" uniqKey="Luk K">KC Luk</name>
</author>
<author><name sortKey="Kehm, V" uniqKey="Kehm V">V Kehm</name>
</author>
<author><name sortKey="Carroll, J" uniqKey="Carroll J">J Carroll</name>
</author>
<author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name>
</author>
<author><name sortKey="O Brien, P" uniqKey="O Brien P">P O'Brien</name>
</author>
<author><name sortKey="Trojanowski, Jq" uniqKey="Trojanowski J">JQ Trojanowski</name>
</author>
<author><name sortKey="Lee, Vm" uniqKey="Lee V">VM Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mougenot, Al" uniqKey="Mougenot A">AL Mougenot</name>
</author>
<author><name sortKey="Nicot, S" uniqKey="Nicot S">S Nicot</name>
</author>
<author><name sortKey="Bencsik, A" uniqKey="Bencsik A">A Bencsik</name>
</author>
<author><name sortKey="Morignat, E" uniqKey="Morignat E">E Morignat</name>
</author>
<author><name sortKey="Verchere, J" uniqKey="Verchere J">J Verchere</name>
</author>
<author><name sortKey="Lakhdar, L" uniqKey="Lakhdar L">L Lakhdar</name>
</author>
<author><name sortKey="Legastelois, S" uniqKey="Legastelois S">S Legastelois</name>
</author>
<author><name sortKey="Baron, T" uniqKey="Baron T">T Baron</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Watts, Jc" uniqKey="Watts J">JC Watts</name>
</author>
<author><name sortKey="Giles, K" uniqKey="Giles K">K Giles</name>
</author>
<author><name sortKey="Oehler, A" uniqKey="Oehler A">A Oehler</name>
</author>
<author><name sortKey="Middleton, L" uniqKey="Middleton L">L Middleton</name>
</author>
<author><name sortKey="Dexter, Dt" uniqKey="Dexter D">DT Dexter</name>
</author>
<author><name sortKey="Gentleman, Sm" uniqKey="Gentleman S">SM Gentleman</name>
</author>
<author><name sortKey="Dearmond, Sj" uniqKey="Dearmond S">SJ Dearmond</name>
</author>
<author><name sortKey="Prusiner, Sb" uniqKey="Prusiner S">SB Prusiner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Masuda Suzukake, M" uniqKey="Masuda Suzukake M">M Masuda-Suzukake</name>
</author>
<author><name sortKey="Nonaka, T" uniqKey="Nonaka T">T Nonaka</name>
</author>
<author><name sortKey="Hosokawa, M" uniqKey="Hosokawa M">M Hosokawa</name>
</author>
<author><name sortKey="Oikawa, T" uniqKey="Oikawa T">T Oikawa</name>
</author>
<author><name sortKey="Arai, T" uniqKey="Arai T">T Arai</name>
</author>
<author><name sortKey="Akiyama, H" uniqKey="Akiyama H">H Akiyama</name>
</author>
<author><name sortKey="Mann, Dm" uniqKey="Mann D">DM Mann</name>
</author>
<author><name sortKey="Hasegawa, M" uniqKey="Hasegawa M">M Hasegawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rey, Nl" uniqKey="Rey N">NL Rey</name>
</author>
<author><name sortKey="Petit, Gh" uniqKey="Petit G">GH Petit</name>
</author>
<author><name sortKey="Bousset, L" uniqKey="Bousset L">L Bousset</name>
</author>
<author><name sortKey="Melki, R" uniqKey="Melki R">R Melki</name>
</author>
<author><name sortKey="Brundin, P" uniqKey="Brundin P">P Brundin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bernis, Me" uniqKey="Bernis M">ME Bernis</name>
</author>
<author><name sortKey="Babila, Jt" uniqKey="Babila J">JT Babila</name>
</author>
<author><name sortKey="Breid, S" uniqKey="Breid S">S Breid</name>
</author>
<author><name sortKey="Wusten, Ka" uniqKey="Wusten K">KA Wusten</name>
</author>
<author><name sortKey="Wullner, U" uniqKey="Wullner U">U Wullner</name>
</author>
<author><name sortKey="Tamguney, G" uniqKey="Tamguney G">G Tamguney</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tamguney, G" uniqKey="Tamguney G">G Tamgüney</name>
</author>
<author><name sortKey="Richt, Ja" uniqKey="Richt J">JA Richt</name>
</author>
<author><name sortKey="Hamir, An" uniqKey="Hamir A">AN Hamir</name>
</author>
<author><name sortKey="Greenlee, Jj" uniqKey="Greenlee J">JJ Greenlee</name>
</author>
<author><name sortKey="Miller, Mw" uniqKey="Miller M">MW Miller</name>
</author>
<author><name sortKey="Wolfe, Ll" uniqKey="Wolfe L">LL Wolfe</name>
</author>
<author><name sortKey="Sirochman, Tm" uniqKey="Sirochman T">TM Sirochman</name>
</author>
<author><name sortKey="Young, Aj" uniqKey="Young A">AJ Young</name>
</author>
<author><name sortKey="Glidden, Dv" uniqKey="Glidden D">DV Glidden</name>
</author>
<author><name sortKey="Johnson, Nl" uniqKey="Johnson N">NL Johnson</name>
</author>
<author><name sortKey="Giles, K" uniqKey="Giles K">K Giles</name>
</author>
<author><name sortKey="Dearmond, Sj" uniqKey="Dearmond S">SJ DeArmond</name>
</author>
<author><name sortKey="Prusiner, Sb" uniqKey="Prusiner S">SB Prusiner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tamguney, G" uniqKey="Tamguney G">G Tamgüney</name>
</author>
<author><name sortKey="Miller, Mw" uniqKey="Miller M">MW Miller</name>
</author>
<author><name sortKey="Wolfe, Ll" uniqKey="Wolfe L">LL Wolfe</name>
</author>
<author><name sortKey="Sirochman, Tm" uniqKey="Sirochman T">TM Sirochman</name>
</author>
<author><name sortKey="Glidden, Dv" uniqKey="Glidden D">DV Glidden</name>
</author>
<author><name sortKey="Palmer, C" uniqKey="Palmer C">C Palmer</name>
</author>
<author><name sortKey="Lemus, A" uniqKey="Lemus A">A Lemus</name>
</author>
<author><name sortKey="Dearmond, Sj" uniqKey="Dearmond S">SJ DeArmond</name>
</author>
<author><name sortKey="Prusiner, Sb" uniqKey="Prusiner S">SB Prusiner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aguzzi, A" uniqKey="Aguzzi A">A Aguzzi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hill, Af" uniqKey="Hill A">AF Hill</name>
</author>
<author><name sortKey="Desbruslais, M" uniqKey="Desbruslais M">M Desbruslais</name>
</author>
<author><name sortKey="Joiner, S" uniqKey="Joiner S">S Joiner</name>
</author>
<author><name sortKey="Sidle, Kc" uniqKey="Sidle K">KC Sidle</name>
</author>
<author><name sortKey="Gowland, I" uniqKey="Gowland I">I Gowland</name>
</author>
<author><name sortKey="Collinge, J" uniqKey="Collinge J">J Collinge</name>
</author>
<author><name sortKey="Doey, Lj" uniqKey="Doey L">LJ Doey</name>
</author>
<author><name sortKey="Lantos, P" uniqKey="Lantos P">P Lantos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hewitt, Pe" uniqKey="Hewitt P">PE Hewitt</name>
</author>
<author><name sortKey="Llewelyn, Ca" uniqKey="Llewelyn C">CA Llewelyn</name>
</author>
<author><name sortKey="Mackenzie, J" uniqKey="Mackenzie J">J Mackenzie</name>
</author>
<author><name sortKey="Will, Rg" uniqKey="Will R">RG Will</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brown, P" uniqKey="Brown P">P Brown</name>
</author>
<author><name sortKey="Brandel, Jp" uniqKey="Brandel J">JP Brandel</name>
</author>
<author><name sortKey="Sato, T" uniqKey="Sato T">T Sato</name>
</author>
<author><name sortKey="Nakamura, Y" uniqKey="Nakamura Y">Y Nakamura</name>
</author>
<author><name sortKey="Mackenzie, J" uniqKey="Mackenzie J">J MacKenzie</name>
</author>
<author><name sortKey="Will, Rg" uniqKey="Will R">RG Will</name>
</author>
<author><name sortKey="Ladogana, A" uniqKey="Ladogana A">A Ladogana</name>
</author>
<author><name sortKey="Pocchiari, M" uniqKey="Pocchiari M">M Pocchiari</name>
</author>
<author><name sortKey="Leschek, Ew" uniqKey="Leschek E">EW Leschek</name>
</author>
<author><name sortKey="Schonberger, Lb" uniqKey="Schonberger L">LB Schonberger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jaunmuktane, Z" uniqKey="Jaunmuktane Z">Z Jaunmuktane</name>
</author>
<author><name sortKey="Mead, S" uniqKey="Mead S">S Mead</name>
</author>
<author><name sortKey="Ellis, M" uniqKey="Ellis M">M Ellis</name>
</author>
<author><name sortKey="Wadsworth, Jd" uniqKey="Wadsworth J">JD Wadsworth</name>
</author>
<author><name sortKey="Nicoll, Aj" uniqKey="Nicoll A">AJ Nicoll</name>
</author>
<author><name sortKey="Kenny, J" uniqKey="Kenny J">J Kenny</name>
</author>
<author><name sortKey="Launchbury, F" uniqKey="Launchbury F">F Launchbury</name>
</author>
<author><name sortKey="Linehan, J" uniqKey="Linehan J">J Linehan</name>
</author>
<author><name sortKey="Richard Loendt, A" uniqKey="Richard Loendt A">A Richard-Loendt</name>
</author>
<author><name sortKey="Walker, As" uniqKey="Walker A">AS Walker</name>
</author>
<author><name sortKey="Rudge, P" uniqKey="Rudge P">P Rudge</name>
</author>
<author><name sortKey="Collinge, J" uniqKey="Collinge J">J Collinge</name>
</author>
<author><name sortKey="Brandner, S" uniqKey="Brandner S">S Brandner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giasson, Bi" uniqKey="Giasson B">BI Giasson</name>
</author>
<author><name sortKey="Duda, Je" uniqKey="Duda J">JE Duda</name>
</author>
<author><name sortKey="Quinn, Sm" uniqKey="Quinn S">SM Quinn</name>
</author>
<author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name>
</author>
<author><name sortKey="Trojanowski, Jq" uniqKey="Trojanowski J">JQ Trojanowski</name>
</author>
<author><name sortKey="Lee, Vm" uniqKey="Lee V">VM Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhu, L" uniqKey="Zhu L">L Zhu</name>
</author>
<author><name sortKey="Ramboz, S" uniqKey="Ramboz S">S Ramboz</name>
</author>
<author><name sortKey="Hewitt, D" uniqKey="Hewitt D">D Hewitt</name>
</author>
<author><name sortKey="Boring, L" uniqKey="Boring L">L Boring</name>
</author>
<author><name sortKey="Grass, Ds" uniqKey="Grass D">DS Grass</name>
</author>
<author><name sortKey="Purchio, Af" uniqKey="Purchio A">AF Purchio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartz, Jc" uniqKey="Bartz J">JC Bartz</name>
</author>
<author><name sortKey="Kincaid, Ae" uniqKey="Kincaid A">AE Kincaid</name>
</author>
<author><name sortKey="Bessen, Ra" uniqKey="Bessen R">RA Bessen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fujiwara, H" uniqKey="Fujiwara H">H Fujiwara</name>
</author>
<author><name sortKey="Hasegawa, M" uniqKey="Hasegawa M">M Hasegawa</name>
</author>
<author><name sortKey="Dohmae, N" uniqKey="Dohmae N">N Dohmae</name>
</author>
<author><name sortKey="Kawashima, A" uniqKey="Kawashima A">A Kawashima</name>
</author>
<author><name sortKey="Masliah, E" uniqKey="Masliah E">E Masliah</name>
</author>
<author><name sortKey="Goldberg, Ms" uniqKey="Goldberg M">MS Goldberg</name>
</author>
<author><name sortKey="Shen, J" uniqKey="Shen J">J Shen</name>
</author>
<author><name sortKey="Takio, K" uniqKey="Takio K">K Takio</name>
</author>
<author><name sortKey="Iwatsubo, T" uniqKey="Iwatsubo T">T Iwatsubo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lowe, J" uniqKey="Lowe J">J Lowe</name>
</author>
<author><name sortKey="Blanchard, A" uniqKey="Blanchard A">A Blanchard</name>
</author>
<author><name sortKey="Morrell, K" uniqKey="Morrell K">K Morrell</name>
</author>
<author><name sortKey="Lennox, G" uniqKey="Lennox G">G Lennox</name>
</author>
<author><name sortKey="Reynolds, L" uniqKey="Reynolds L">L Reynolds</name>
</author>
<author><name sortKey="Billett, M" uniqKey="Billett M">M Billett</name>
</author>
<author><name sortKey="Landon, M" uniqKey="Landon M">M Landon</name>
</author>
<author><name sortKey="Mayer, Rj" uniqKey="Mayer R">RJ Mayer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuusisto, E" uniqKey="Kuusisto E">E Kuusisto</name>
</author>
<author><name sortKey="Salminen, A" uniqKey="Salminen A">A Salminen</name>
</author>
<author><name sortKey="Alafuzoff, I" uniqKey="Alafuzoff I">I Alafuzoff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eisele, Ys" uniqKey="Eisele Y">YS Eisele</name>
</author>
<author><name sortKey="Obermuller, U" uniqKey="Obermuller U">U Obermuller</name>
</author>
<author><name sortKey="Heilbronner, G" uniqKey="Heilbronner G">G Heilbronner</name>
</author>
<author><name sortKey="Baumann, F" uniqKey="Baumann F">F Baumann</name>
</author>
<author><name sortKey="Kaeser, Sa" uniqKey="Kaeser S">SA Kaeser</name>
</author>
<author><name sortKey="Wolburg, H" uniqKey="Wolburg H">H Wolburg</name>
</author>
<author><name sortKey="Walker, Lc" uniqKey="Walker L">LC Walker</name>
</author>
<author><name sortKey="Staufenbiel, M" uniqKey="Staufenbiel M">M Staufenbiel</name>
</author>
<author><name sortKey="Heikenwalder, M" uniqKey="Heikenwalder M">M Heikenwalder</name>
</author>
<author><name sortKey="Jucker, M" uniqKey="Jucker M">M Jucker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clavaguera, F" uniqKey="Clavaguera F">F Clavaguera</name>
</author>
<author><name sortKey="Hench, J" uniqKey="Hench J">J Hench</name>
</author>
<author><name sortKey="Lavenir, I" uniqKey="Lavenir I">I Lavenir</name>
</author>
<author><name sortKey="Schweighauser, G" uniqKey="Schweighauser G">G Schweighauser</name>
</author>
<author><name sortKey="Frank, S" uniqKey="Frank S">S Frank</name>
</author>
<author><name sortKey="Goedert, M" uniqKey="Goedert M">M Goedert</name>
</author>
<author><name sortKey="Tolnay, M" uniqKey="Tolnay M">M Tolnay</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Siso, S" uniqKey="Siso S">S Siso</name>
</author>
<author><name sortKey="Gonzalez, L" uniqKey="Gonzalez L">L Gonzalez</name>
</author>
<author><name sortKey="Jeffrey, M" uniqKey="Jeffrey M">M Jeffrey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Braak, H" uniqKey="Braak H">H Braak</name>
</author>
<author><name sortKey="De Vos, Ra" uniqKey="De Vos R">RA de Vos</name>
</author>
<author><name sortKey="Bohl, J" uniqKey="Bohl J">J Bohl</name>
</author>
<author><name sortKey="Del Tredici, K" uniqKey="Del Tredici K">K Del Tredici</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hawkes, Ch" uniqKey="Hawkes C">CH Hawkes</name>
</author>
<author><name sortKey="Del Tredici, K" uniqKey="Del Tredici K">K Del Tredici</name>
</author>
<author><name sortKey="Braak, H" uniqKey="Braak H">H Braak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ulusoy, A" uniqKey="Ulusoy A">A Ulusoy</name>
</author>
<author><name sortKey="Rusconi, R" uniqKey="Rusconi R">R Rusconi</name>
</author>
<author><name sortKey="Perez Revuelta, Bi" uniqKey="Perez Revuelta B">BI Perez-Revuelta</name>
</author>
<author><name sortKey="Musgrove, Re" uniqKey="Musgrove R">RE Musgrove</name>
</author>
<author><name sortKey="Helwig, M" uniqKey="Helwig M">M Helwig</name>
</author>
<author><name sortKey="Winzen Reichert, B" uniqKey="Winzen Reichert B">B Winzen-Reichert</name>
</author>
<author><name sortKey="Di Monte, Da" uniqKey="Di Monte D">DA Di Monte</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Holmqvist, S" uniqKey="Holmqvist S">S Holmqvist</name>
</author>
<author><name sortKey="Chutna, O" uniqKey="Chutna O">O Chutna</name>
</author>
<author><name sortKey="Bousset, L" uniqKey="Bousset L">L Bousset</name>
</author>
<author><name sortKey="Aldrin Kirk, P" uniqKey="Aldrin Kirk P">P Aldrin-Kirk</name>
</author>
<author><name sortKey="Li, W" uniqKey="Li W">W Li</name>
</author>
<author><name sortKey="Bjorklund, T" uniqKey="Bjorklund T">T Bjorklund</name>
</author>
<author><name sortKey="Wang, Zy" uniqKey="Wang Z">ZY Wang</name>
</author>
<author><name sortKey="Roybon, L" uniqKey="Roybon L">L Roybon</name>
</author>
<author><name sortKey="Melki, R" uniqKey="Melki R">R Melki</name>
</author>
<author><name sortKey="Li, Jy" uniqKey="Li J">JY Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sacino, An" uniqKey="Sacino A">AN Sacino</name>
</author>
<author><name sortKey="Brooks, M" uniqKey="Brooks M">M Brooks</name>
</author>
<author><name sortKey="Thomas, Ma" uniqKey="Thomas M">MA Thomas</name>
</author>
<author><name sortKey="Mckinney, Ab" uniqKey="Mckinney A">AB McKinney</name>
</author>
<author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name>
</author>
<author><name sortKey="Regenhardt, Rw" uniqKey="Regenhardt R">RW Regenhardt</name>
</author>
<author><name sortKey="Mcgarvey, Nh" uniqKey="Mcgarvey N">NH McGarvey</name>
</author>
<author><name sortKey="Ayers, Ji" uniqKey="Ayers J">JI Ayers</name>
</author>
<author><name sortKey="Notterpek, L" uniqKey="Notterpek L">L Notterpek</name>
</author>
<author><name sortKey="Borchelt, Dr" uniqKey="Borchelt D">DR Borchelt</name>
</author>
<author><name sortKey="Golde, Te" uniqKey="Golde T">TE Golde</name>
</author>
<author><name sortKey="Giasson, Bi" uniqKey="Giasson B">BI Giasson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peelaerts, W" uniqKey="Peelaerts W">W Peelaerts</name>
</author>
<author><name sortKey="Bousset, L" uniqKey="Bousset L">L Bousset</name>
</author>
<author><name sortKey="Van Der Perren, A" uniqKey="Van Der Perren A">A Van der Perren</name>
</author>
<author><name sortKey="Moskalyuk, A" uniqKey="Moskalyuk A">A Moskalyuk</name>
</author>
<author><name sortKey="Pulizzi, R" uniqKey="Pulizzi R">R Pulizzi</name>
</author>
<author><name sortKey="Giugliano, M" uniqKey="Giugliano M">M Giugliano</name>
</author>
<author><name sortKey="Van Den Haute, C" uniqKey="Van Den Haute C">C Van den Haute</name>
</author>
<author><name sortKey="Melki, R" uniqKey="Melki R">R Melki</name>
</author>
<author><name sortKey="Baekelandt, V" uniqKey="Baekelandt V">V Baekelandt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beach, Tg" uniqKey="Beach T">TG Beach</name>
</author>
<author><name sortKey="Adler, Ch" uniqKey="Adler C">CH Adler</name>
</author>
<author><name sortKey="Sue, Li" uniqKey="Sue L">LI Sue</name>
</author>
<author><name sortKey="Vedders, L" uniqKey="Vedders L">L Vedders</name>
</author>
<author><name sortKey="Lue, L" uniqKey="Lue L">L Lue</name>
</author>
<author><name sortKey="White, Cl" uniqKey="White C">CL White</name>
</author>
<author><name sortKey="Akiyama, H" uniqKey="Akiyama H">H Akiyama</name>
</author>
<author><name sortKey="Caviness, Jn" uniqKey="Caviness J">JN Caviness</name>
</author>
<author><name sortKey="Shill, Ha" uniqKey="Shill H">HA Shill</name>
</author>
<author><name sortKey="Sabbagh, Mn" uniqKey="Sabbagh M">MN Sabbagh</name>
</author>
<author><name sortKey="Walker, Dg" uniqKey="Walker D">DG Walker</name>
</author>
<author><name sortKey="Arizona Parkinson, S Disease Consortium" uniqKey="Arizona Parkinson ">'s Disease Consortium Arizona Parkinson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cersosimo, Mg" uniqKey="Cersosimo M">MG Cersosimo</name>
</author>
<author><name sortKey="Benarroch, Ee" uniqKey="Benarroch E">EE Benarroch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gelpi, E" uniqKey="Gelpi E">E Gelpi</name>
</author>
<author><name sortKey="Navarro Otano, J" uniqKey="Navarro Otano J">J Navarro-Otano</name>
</author>
<author><name sortKey="Tolosa, E" uniqKey="Tolosa E">E Tolosa</name>
</author>
<author><name sortKey="Gaig, C" uniqKey="Gaig C">C Gaig</name>
</author>
<author><name sortKey="Compta, Y" uniqKey="Compta Y">Y Compta</name>
</author>
<author><name sortKey="Rey, Mj" uniqKey="Rey M">MJ Rey</name>
</author>
<author><name sortKey="Marti, Mj" uniqKey="Marti M">MJ Marti</name>
</author>
<author><name sortKey="Hernandez, I" uniqKey="Hernandez I">I Hernandez</name>
</author>
<author><name sortKey="Valldeoriola, F" uniqKey="Valldeoriola F">F Valldeoriola</name>
</author>
<author><name sortKey="Rene, R" uniqKey="Rene R">R Rene</name>
</author>
<author><name sortKey="Ribalta, T" uniqKey="Ribalta T">T Ribalta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hilton, D" uniqKey="Hilton D">D Hilton</name>
</author>
<author><name sortKey="Stephens, M" uniqKey="Stephens M">M Stephens</name>
</author>
<author><name sortKey="Kirk, L" uniqKey="Kirk L">L Kirk</name>
</author>
<author><name sortKey="Edwards, P" uniqKey="Edwards P">P Edwards</name>
</author>
<author><name sortKey="Potter, R" uniqKey="Potter R">R Potter</name>
</author>
<author><name sortKey="Zajicek, J" uniqKey="Zajicek J">J Zajicek</name>
</author>
<author><name sortKey="Broughton, E" uniqKey="Broughton E">E Broughton</name>
</author>
<author><name sortKey="Hagan, H" uniqKey="Hagan H">H Hagan</name>
</author>
<author><name sortKey="Carroll, C" uniqKey="Carroll C">C Carroll</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zange, L" uniqKey="Zange L">L Zange</name>
</author>
<author><name sortKey="Noack, C" uniqKey="Noack C">C Noack</name>
</author>
<author><name sortKey="Hahn, K" uniqKey="Hahn K">K Hahn</name>
</author>
<author><name sortKey="Stenzel, W" uniqKey="Stenzel W">W Stenzel</name>
</author>
<author><name sortKey="Lipp, A" uniqKey="Lipp A">A Lipp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bruce, Me" uniqKey="Bruce M">ME Bruce</name>
</author>
<author><name sortKey="Mcconnell, I" uniqKey="Mcconnell I">I McConnell</name>
</author>
<author><name sortKey="Will, Rg" uniqKey="Will R">RG Will</name>
</author>
<author><name sortKey="Ironside, Jw" uniqKey="Ironside J">JW Ironside</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcculloch, L" uniqKey="Mcculloch L">L McCulloch</name>
</author>
<author><name sortKey="Brown, Kl" uniqKey="Brown K">KL Brown</name>
</author>
<author><name sortKey="Bradford, Bm" uniqKey="Bradford B">BM Bradford</name>
</author>
<author><name sortKey="Hopkins, J" uniqKey="Hopkins J">J Hopkins</name>
</author>
<author><name sortKey="Bailey, M" uniqKey="Bailey M">M Bailey</name>
</author>
<author><name sortKey="Rajewsky, K" uniqKey="Rajewsky K">K Rajewsky</name>
</author>
<author><name sortKey="Manson, Jc" uniqKey="Manson J">JC Manson</name>
</author>
<author><name sortKey="Mabbott, Na" uniqKey="Mabbott N">NA Mabbott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Glatzel, M" uniqKey="Glatzel M">M Glatzel</name>
</author>
<author><name sortKey="Abela, E" uniqKey="Abela E">E Abela</name>
</author>
<author><name sortKey="Maissen, M" uniqKey="Maissen M">M Maissen</name>
</author>
<author><name sortKey="Aguzzi, A" uniqKey="Aguzzi A">A Aguzzi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barbour, R" uniqKey="Barbour R">R Barbour</name>
</author>
<author><name sortKey="Kling, K" uniqKey="Kling K">K Kling</name>
</author>
<author><name sortKey="Anderson, Jp" uniqKey="Anderson J">JP Anderson</name>
</author>
<author><name sortKey="Banducci, K" uniqKey="Banducci K">K Banducci</name>
</author>
<author><name sortKey="Cole, T" uniqKey="Cole T">T Cole</name>
</author>
<author><name sortKey="Diep, L" uniqKey="Diep L">L Diep</name>
</author>
<author><name sortKey="Fox, M" uniqKey="Fox M">M Fox</name>
</author>
<author><name sortKey="Goldstein, Jm" uniqKey="Goldstein J">JM Goldstein</name>
</author>
<author><name sortKey="Soriano, F" uniqKey="Soriano F">F Soriano</name>
</author>
<author><name sortKey="Seubert, P" uniqKey="Seubert P">P Seubert</name>
</author>
<author><name sortKey="Chilcote, Tj" uniqKey="Chilcote T">TJ Chilcote</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rudge, P" uniqKey="Rudge P">P Rudge</name>
</author>
<author><name sortKey="Jaunmuktane, Z" uniqKey="Jaunmuktane Z">Z Jaunmuktane</name>
</author>
<author><name sortKey="Adlard, P" uniqKey="Adlard P">P Adlard</name>
</author>
<author><name sortKey="Bjurstrom, N" uniqKey="Bjurstrom N">N Bjurstrom</name>
</author>
<author><name sortKey="Caine, D" uniqKey="Caine D">D Caine</name>
</author>
<author><name sortKey="Lowe, J" uniqKey="Lowe J">J Lowe</name>
</author>
<author><name sortKey="Norsworthy, P" uniqKey="Norsworthy P">P Norsworthy</name>
</author>
<author><name sortKey="Hummerich, H" uniqKey="Hummerich H">H Hummerich</name>
</author>
<author><name sortKey="Druyeh, R" uniqKey="Druyeh R">R Druyeh</name>
</author>
<author><name sortKey="Wadsworth, Jd" uniqKey="Wadsworth J">JD Wadsworth</name>
</author>
<author><name sortKey="Brandner, S" uniqKey="Brandner S">S Brandner</name>
</author>
<author><name sortKey="Hyare, H" uniqKey="Hyare H">H Hyare</name>
</author>
<author><name sortKey="Mead, S" uniqKey="Mead S">S Mead</name>
</author>
<author><name sortKey="Collinge, J" uniqKey="Collinge J">J Collinge</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Frontzek, K" uniqKey="Frontzek K">K Frontzek</name>
</author>
<author><name sortKey="Lutz, Mi" uniqKey="Lutz M">MI Lutz</name>
</author>
<author><name sortKey="Aguzzi, A" uniqKey="Aguzzi A">A Aguzzi</name>
</author>
<author><name sortKey="Kovacs, Gg" uniqKey="Kovacs G">GG Kovacs</name>
</author>
<author><name sortKey="Budka, H" uniqKey="Budka H">H Budka</name>
</author>
</analytic>
</biblStruct>
</listBibl>
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</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Canada</li>
</country>
<region><li>District de Cologne</li>
<li>Rhénanie-du-Nord-Westphalie</li>
</region>
<settlement><li>Bonn</li>
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<tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Breid, Sara" sort="Breid, Sara" uniqKey="Breid S" first="Sara" last="Breid">Sara Breid</name>
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<name sortKey="Bernis, Maria E" sort="Bernis, Maria E" uniqKey="Bernis M" first="Maria E." last="Bernis">Maria E. Bernis</name>
<name sortKey="Tamguney, Gultekin" sort="Tamguney, Gultekin" uniqKey="Tamguney G" first="Gültekin" last="Tamgüney">Gültekin Tamgüney</name>
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